Ginseng, particularly species such as Panax ginseng and Panax quinquefolius, has a long history of traditional use as a general tonic and adaptogen, believed to support energy, vitality, and overall well-being. In terms of the glandular system (which includes glands such as the adrenal, pituitary, and thyroid), modern scientific studies have investigated ginseng's effects primarily on stress response, adrenal function, and hormonal balance. Several studies suggest that ginsenosides, the primary active compounds in ginseng, may help modulate the hypothalamic-pituitary-adrenal (HPA) axis, which is central to the body's hormonal and stress response systems. There is evidence from animal and some human studies that ginseng may reduce cortisol levels, support adrenal function, and influence other hormone levels, potentially helping the body adapt to physical and mental stressors.

However, while these findings are promising, high-quality clinical trials in humans are limited, and results are sometimes inconsistent. The evidence is stronger for ginseng's adaptogenic effects (i.e., supporting the body's resistance to stress), which is often considered a glandular system function. Overall, the use of ginseng to support the glandular system is justified by both tradition and a moderate level of scientific evidence, particularly regarding its adaptogenic and stress-modulating properties, but it cannot be considered firmly established for all glandular-related conditions.