Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Eurycomanone is a quassinoid compound found in the roots of Eurycoma longifolia, commonly known as tongkat ali or longjack. Traditionally, tongkat ali has been used in Southeast Asian herbal medicine as a general tonic and to enhance male vitality, which is often linked to the support of the glandular (endocrine) system, particularly regarding testosterone production and reproductive health. Historical use centers on claims of increased energy, libido, and improved male fertility, suggesting a role in supporting glands such as the testes and possibly the adrenal glands. However, while eurycomanone is considered one of the primary bioactive constituents responsible for these effects, direct scientific research on eurycomanone itself—distinct from whole tongkat ali extracts—is limited. The evidence supporting its effect on the glandular system is mostly derived from traditional use and a small number of in vitro and animal studies indicating androgenic or anti-estrogenic effects, but robust clinical data in humans is lacking. Therefore, the use of eurycomanone for glandular system support is primarily justified by traditional practices rather than strong scientific validation.

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