Flavonoid glycosides are plant-derived compounds with notable antioxidant and anti-inflammatory properties. Their use in supporting or treating gingivitis is primarily justified by emerging scientific research, rather than tradition. Several in vitro and clinical studies have explored the effects of flavonoid-rich extracts (such as those from Ginkgo biloba, citrus fruits, and propolis) on periodontal health. The rationale for their use in gingivitis centers on their ability to reduce inflammatory mediators (such as interleukin-1β and tumor necrosis factor-alpha) and inhibit oxidative stress in the gingival tissues. Some randomized controlled trials suggest that topical or oral supplementation with flavonoid glycosides can decrease gingival bleeding, reduce plaque accumulation, and improve clinical indices of gingivitis, although the sample sizes and methodologies of these studies are sometimes limited.

Notably, a 2022 systematic review (e.g., PMID: 35336351) concluded that while flavonoids appear promising as adjuncts in the management of gingivitis, the overall quality of evidence is moderate, and more robust, large-scale studies are needed. The mechanism of action is thought to involve the scavenging of free radicals and modulation of inflammatory pathways in the periodontal tissues. Therefore, while there is scientific validation for the use of flavonoid glycosides in gingivitis, it is still considered adjunctive and not a replacement for standard care such as mechanical plaque removal.