Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Enzymes, particularly proteolytic enzymes such as bromelain, papain, and bacterial-derived enzymes (e.g., from Streptococcus species), have been investigated for their role as adjunctive agents in the treatment of gingivitis. Their primary proposed mechanism is the breakdown of dental biofilm and reduction of inflammation. Several commercial oral care products (toothpastes and mouthwashes) contain enzymes for this purpose.

Some clinical trials and systematic reviews suggest that enzyme-containing oral hygiene products may help reduce plaque accumulation and gingival inflammation compared to placebo. For example, a few randomized controlled trials have shown that enzyme-containing toothpastes can lead to modest improvements in gingival health, particularly when used in conjunction with regular mechanical cleaning. However, the evidence base is limited: studies often have small sample sizes, short durations, or methodological weaknesses. The overall clinical impact is usually described as modest, and enzymes are not considered a replacement for standard oral hygiene practices.

Major dental organizations do not specifically recommend enzyme products over traditional mechanical cleaning or antiseptic agents for gingivitis, but recognize their potential as adjuncts. In summary, while there is some scientific evidence supporting the use of enzymes for gingivitis, the strength and quality of this evidence is moderate to low.

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Other ingredients used for Gingivitis

Other health conditions supported by Enzyme (unspecified)

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