Evidence supporting the use of: Goldenseal
For the health condition: Giardia

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Goldenseal (Hydrastis canadensis) has a long history of use in traditional herbal medicine, particularly among Native American tribes and early American settlers. It was commonly used as a remedy for various digestive complaints, including diarrhea and infections such as those caused by Giardia lamblia, a protozoan parasite responsible for giardiasis. The rationale for its use is largely based on goldenseal’s content of berberine, an isoquinoline alkaloid with broad-spectrum antimicrobial properties. Berberine has demonstrated activity against a range of pathogens in vitro, including some protozoa. However, while laboratory studies suggest berberine can inhibit Giardia, the evidence is largely preclinical and limited to cell culture or animal models. There is a lack of well-conducted clinical trials in humans to confirm efficacy or safety for giardiasis. Thus, while goldenseal’s use for Giardia is supported by tradition and plausible mechanistic reasoning, it currently lacks strong scientific validation. Its use persists in herbal medicine for digestive infections, but mainstream medical guidelines do not endorse it as a treatment for giardiasis. Caution is advised due to potential toxicity and drug interactions associated with berberine-containing herbs.

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