Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Glucofrangulin is a compound found in the bark of certain Rhamnus species, primarily Rhamnus frangula (buckthorn). Its primary historical use is as an anthraquinone glycoside with laxative effects, traditionally used to relieve constipation. In traditional herbal medicine, especially in European phytotherapy, buckthorn bark preparations (containing glucofrangulin) were sometimes employed for a range of digestive complaints, including bloating and gas, based on the belief that improving bowel regularity and relieving constipation also alleviates these symptoms. However, the direct use of glucofrangulin specifically to treat gas and bloating lacks robust documentation even in traditional sources, and there is an absence of scientific studies validating its efficacy for these purposes. Most references to glucofrangulin or buckthorn bark focus on their laxative effect rather than on actions against flatulence or bloating. Thus, while there is a weak traditional rationale for its use in digestive complaints, the evidence is indirect and limited. No clinical trials or pharmacological studies have established glucofrangulin as a treatment for gas or bloating. Its use in this context is primarily justified by tradition, and the supporting evidence is minimal.

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