Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Alpha-galactosidase is an enzyme that breaks down complex carbohydrates, specifically oligosaccharides such as raffinose and stachyose, which are found in foods like beans, legumes, and some vegetables. Humans lack sufficient endogenous alpha-galactosidase in the digestive tract, so when these carbohydrates are not fully digested in the small intestine, they pass into the colon, where bacteria ferment them, producing gas and resulting in symptoms like bloating and flatulence.

There is substantial scientific evidence to support the use of alpha-galactosidase supplements for reducing gas and bloating. Randomized controlled trials (RCTs) have demonstrated that oral alpha-galactosidase, taken with meals containing gas-producing foods, significantly reduces the amount of hydrogen (a marker of colonic fermentation) in breath tests and decreases self-reported symptoms of bloating and flatulence. One of the best-known commercial preparations, Beano, is a source of this enzyme and has been specifically studied in clinical settings. A meta-analysis published in 2015 concluded that alpha-galactosidase supplementation is effective and safe for decreasing symptoms of gas and abdominal discomfort in otherwise healthy individuals consuming a high-fiber diet.

Thus, the use of alpha-galactosidase for the management of gas and bloating is scientifically validated, particularly for individuals whose symptoms are triggered by high-fiber, oligosaccharide-rich foods.

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Products containing alpha-galactosidase

Nature's Sunshine Proactazyme®