Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Oxygen, specifically in the form of hyperbaric oxygen therapy (HBOT), is scientifically validated as a supportive treatment for certain forms of gangrene, particularly clostridial myonecrosis (gas gangrene). HBOT involves placing the patient in a pressurized chamber where they breathe 100% oxygen. This process significantly increases the amount of dissolved oxygen in the blood, promoting wound healing and inhibiting the growth of anaerobic bacteria, such as Clostridium perfringens, which are responsible for gas gangrene. Multiple clinical studies and consensus guidelines, including those from the Undersea and Hyperbaric Medical Society (UHMS), support the use of HBOT as an adjunct to surgical debridement and antibiotics in the management of necrotizing soft tissue infections and gangrene. The increased tissue oxygenation enhances leukocyte function, promotes angiogenesis, and helps in toxin inactivation. While HBOT is not a replacement for surgery or antibiotics, it is a well-established adjunctive therapy. Systematic reviews and case series over several decades have demonstrated improved outcomes and limb salvage rates in patients with gangrene treated with HBOT alongside standard medical and surgical interventions.

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