Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Glycocholic acid is a bile acid conjugate naturally produced in the liver by combining cholic acid with glycine. Its primary physiological role is to facilitate the digestion and absorption of dietary fats by emulsifying lipids in the small intestine. Glycocholic acid, along with other bile acids, is critical for normal gall bladder function and bile flow. In clinical practice, bile acids (including glycocholic acid and their derivatives) have been used as therapeutic agents to dissolve cholesterol gallstones and to treat certain cholestatic liver diseases.

Scientific evidence supports the use of bile acids, particularly ursodeoxycholic acid (a related compound), for gall bladder-related conditions. While glycocholic acid itself is less commonly administered directly as a supplement or medication, it is a physiological component of bile and is sometimes included in “ox bile” or “bile salt” supplements aimed at supporting gall bladder and digestive health. Studies have shown that bile acids can enhance bile flow and help prevent gallstone formation by solubilizing cholesterol.

However, direct supplementation with glycocholic acid is less well-studied compared to other bile acids. Most clinical evidence pertains to overall bile acid therapy rather than isolated glycocholic acid. Nevertheless, its physiological role and the body of research on bile acids in general provide a reasonable scientific basis for its use in supporting the gall bladder body system.

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