Evidence supporting the use of: Vitamin B6
For the body system: GABA
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin B6 (pyridoxine) has scientific support for its role in supporting the GABA (gamma-aminobutyric acid) system in the body. B6 acts as a coenzyme for glutamate decarboxylase, the enzyme that converts glutamate (an excitatory neurotransmitter) into GABA (the primary inhibitory neurotransmitter in the central nervous system). Without adequate B6, this enzymatic conversion is impaired, potentially leading to decreased GABA synthesis. Several studies have shown that B6 deficiency can lower brain GABA levels, resulting in neurological symptoms such as irritability, nervousness, and even seizures in severe cases. Supplementation with vitamin B6 has been used therapeutically in some neurological conditions, such as epilepsy, where GABA function is relevant. However, while the biochemical necessity of B6 for GABA production is clear, direct clinical trials evaluating B6 supplementation for enhancing GABAergic function or treating anxiety or mood disorders are limited. Most evidence is mechanistic or based on deficiency states rather than robust clinical outcomes in otherwise healthy individuals. Thus, while B6 is scientifically justified for supporting the GABA system, the strength of clinical evidence for its use in modulating GABA-related health conditions is moderate.
Other ingredients that support GABA
amino acidsashwagandha
California poppy
chamomile
hops
kava root
l-taurine
l-theanine
lactium casein decapeptide
lactobacillus brevis
lavender
magnesium
magnolia
passionflower
phytocannabinoids
polygala root
skullcap
valerian root
vitamin B6
gastrodia
kanna
7,4-Dimethoxyflavone
7-Methoxyflavone
Apigenin
Baccosides
Brahmi
Capitate Valerian
Convolvulus prostratus
Convolvulus Pluricaulis
Dihydromyricetin
Erythrina
Products containing vitamin B6
Nature's Sunshine 5-HTP Power
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Clean Energy
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine Balanced B Complex (Vitamin B)
Nature's Sunshine Cardio Assurance
Nature's Sunshine Children's MultiVitamin & Mineral
Nature's Sunshine Glandular System
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Liquid - Methyl Vitamin B-12 Complete
Nature's Sunshine Love and Peas
Nature's Sunshine Mega-Chel
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Nutri-Calm
Nature's Sunshine Nutri-Calm
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Power Greens
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal
Nature's Sunshine Power Meal
Nature's Sunshine Silver Shield BioGuard Hand & Body Cream
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Energy
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Thyroid Support
Nature's Sunshine B-Complex
Nature's Sunshine Vitamin B6
Nature's Sunshine VitaWave
