Convolvulus pluricaulis, commonly known as Shankhpushpi, is a prominent herb in traditional Ayurvedic medicine, where it has been used for centuries as a "medhya rasayana"—a rejuvenator for the mind. Its traditional applications include support for cognitive function, anxiolytic effects, and as a remedy for stress and insomnia. These uses are based on ancient Ayurvedic texts and continued practice in traditional Indian medicine, which often attribute calming and relaxing effects to the herb, suggesting an indirect support of the GABAergic system responsible for inhibitory neurotransmission and anxiety modulation.

Scientific evidence specifically linking Convolvulus pluricaulis to the GABA system is limited and largely preliminary. Some animal studies and in vitro experiments have suggested anxiolytic and sedative effects, possibly through modulation of neurotransmitters, but direct evidence of significant GABAergic activity is sparse and not well-characterized. The majority of available studies are either not peer-reviewed, have small sample sizes, or lack rigorous controls. Thus, while the traditional use is strong and some early scientific indications exist, robust clinical evidence to support its use specifically for the GABA system is lacking.