Evidence supporting the use of: Ashwagandha
For the body system: GABA

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ashwagandha (Withania somnifera) has been traditionally used in Ayurvedic medicine for its adaptogenic and calming properties, but more recently, scientific studies have begun to elucidate its potential effects on the GABAergic system. GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system, and modulation of GABA activity is associated with reduced anxiety and improved relaxation. Several preclinical studies (in vitro and in animal models) have demonstrated that ashwagandha extracts may bind to GABAA receptors or enhance GABAergic signaling. For example, Phytomedicine (2000) published research indicating that ashwagandha’s constituents may act as GABA mimetics. Some small human clinical trials have reported reductions in anxiety and stress symptoms with ashwagandha supplementation, consistent with effects seen from GABAergic modulation, but these studies typically do not directly measure GABA levels or receptor binding in humans. Overall, the evidence for ashwagandha’s support of the GABAergic system is promising but still emerging. While animal and in vitro studies suggest mechanisms relevant to GABA, and human studies show relevant clinical effects, direct evidence in humans remains limited. Thus, the use of ashwagandha to support the GABA system is supported by scientific evidence, but the strength of this evidence can be considered moderate (3/5) at this time.

More about ashwagandha
More about GABA