Evidence supporting the use of: Terpinen-4-ol
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Terpinen-4-ol is a major active ingredient in tea tree oil (Melaleuca alternifolia), and its use for supporting or treating fungal infections is supported by scientific evidence. Multiple in vitro studies have demonstrated that terpinen-4-ol exhibits significant antifungal activity against a range of pathogenic fungi, including Candida albicans, Trichophyton rubrum, and other dermatophytes responsible for skin and nail infections. The mechanism of action is believed to involve disruption of fungal cell membrane integrity, leading to leakage of cellular contents and cell death.

Clinical studies and randomized controlled trials using tea tree oil preparations (containing high concentrations of terpinen-4-ol) have shown efficacy in conditions such as onychomycosis (fungal nail infection) and tinea pedis (athlete’s foot), although results can be mixed and tea tree oil is generally less effective than standard pharmaceutical antifungals. Nonetheless, terpinen-4-ol is regarded as the primary component responsible for tea tree oil’s antifungal effects. A notable example is a randomized trial published in the Journal of Family Practice (1994), where 100% tea tree oil was as effective as clotrimazole in treating toenail onychomycosis in some participants. Safety concerns are minimal when used topically, though allergic reactions can occur.

In summary, the use of terpinen-4-ol for fungal infections is based on both in vitro and clinical evidence, justifying its consideration as an adjunct or alternative treatment, particularly for mild superficial infections.

More about Terpinen-4-ol
More about Fungal Infections

Products containing Terpinen-4-ol

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