Pine, particularly in the form of pine resin, pine tar, or pine essential oils (such as those from Pinus sylvestris or Pinus pinaster), has a long history of use in traditional medicine for treating skin conditions, including fungal infections like athlete’s foot and ringworm. Ethnobotanical records document the application of pine extracts and resins by various cultures as antiseptics and antimicrobial agents. The rationale for these uses arises from the resin’s sticky, protective qualities and the aromatic compounds' perceived cleansing effects. Some laboratory studies have shown that pine-derived compounds (such as alpha-pinene and beta-pinene) possess mild antifungal activity against certain dermatophytes and yeasts in vitro. However, these findings are limited, and there is a lack of robust clinical trials demonstrating efficacy or safety in treating human fungal infections. Modern medical guidelines do not endorse pine products as standard therapy for fungal infections, due to insufficient clinical evidence. In summary, pine’s use against fungal infections is primarily supported by tradition and some preliminary laboratory data, but scientific validation is limited. Its effectiveness in clinical practice remains unproven, and more rigorous studies are needed to clarify its potential role.