Evidence supporting the use of: Oregon grape
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oregon grape (Mahonia aquifolium) is used to support/treat fungal infections primarily due to its content of berberine, an isoquinoline alkaloid known for antimicrobial properties. Although the use of Oregon grape has roots in traditional herbal medicine—Native American and Western herbalists have used it for skin conditions—the scientific foundation centers on berberine’s antifungal activity. In vitro studies have demonstrated that extracts of Oregon grape and purified berberine can inhibit the growth of several fungal species, including Candida albicans and Trichophyton species, which are common causes of skin and mucous membrane infections. For example, a 2011 study published in “Phytotherapy Research” found that Mahonia aquifolium extracts exhibited significant antifungal activity against dermatophytes and yeasts.

However, most of the evidence comes from laboratory (in vitro) studies rather than clinical trials in humans. There are a few small clinical studies and case reports suggesting efficacy for topical use in conditions such as psoriasis, but direct evidence for treating fungal infections in humans is limited. The mechanism of action is thought to involve berberine’s ability to disrupt fungal cell membranes and inhibit their growth. While preclinical research is promising, the overall quality and quantity of clinical evidence are insufficient to make strong recommendations for use. Thus, the evidence rating is moderate but not robust, and further clinical research is needed to confirm efficacy and safety in humans.

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