Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Monolaurin, a monoglyceride derived from lauric acid (found in coconut oil and breast milk), has gained attention for its antimicrobial properties, including potential activity against certain fungi. Laboratory (in vitro) studies have shown that monolaurin can disrupt the lipid membranes of various pathogens, including fungi such as Candida albicans. These effects are attributed to its ability to solubilize the lipids in microbial cell membranes, leading to cell disintegration and death.

Despite these promising laboratory findings, clinical evidence in humans remains limited. Most support for monolaurin’s antifungal use comes from cell culture and animal research, which cannot be directly extrapolated to humans. There are some anecdotal and preliminary reports suggesting benefit for fungal infections when monolaurin is used as a dietary supplement, but large-scale clinical trials are lacking.

Overall, while there is a plausible scientific rationale and some laboratory evidence for the antifungal effects of monolaurin, there is not yet robust clinical data supporting its efficacy in treating or preventing fungal infections in humans. Therefore, the strength of evidence is rated as 2, reflecting promising preclinical data but limited direct human research. Individuals considering monolaurin for fungal infections should consult a healthcare provider, as traditional antifungal medications have a more established safety and efficacy profile.

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