Evidence supporting the use of: Mahonia (unspecified)
For the health condition: Fungal Infections

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Mahonia (commonly Mahonia aquifolium, also known as Oregon grape) has a history of traditional use in herbal medicine, particularly among Native American and European herbalists, for various skin conditions including fungal infections such as athlete’s foot and ringworm. This traditional usage stems from Mahonia’s content of berberine and related alkaloids, compounds known for their broad-spectrum antimicrobial properties. While berberine, in vitro, has demonstrated antifungal activity against several species including Candida and Trichophyton, scientific studies specifically examining Mahonia extracts for fungal infections in humans are very limited. Most available evidence is anecdotal or derived from broader studies on berberine-containing plants rather than Mahonia itself. Clinical trials on Mahonia have focused more on psoriasis, eczema, and general skin inflammation rather than fungal diseases. Therefore, while there is a reasonable traditional basis for its use against fungal infections, and some mechanistic rationale from berberine’s properties, scientific validation for Mahonia’s efficacy in treating fungal infections is currently weak and largely untested in rigorous clinical settings.

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