Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tangeretin is a polymethoxylated flavone found predominantly in citrus peels, especially tangerines. Its use for supporting or treating free radical damage is primarily justified by preclinical scientific evidence. Multiple in vitro (test tube) and animal studies have demonstrated that tangeretin possesses antioxidant properties, meaning it can neutralize or scavenge free radicals—unstable molecules that can damage cells and contribute to aging and various diseases. For example, research has shown that tangeretin can increase the activity of antioxidant enzymes like superoxide dismutase (SOD) and catalase, and reduce oxidative stress markers in animal models. These findings suggest that tangeretin may help mitigate oxidative damage at the cellular level.

However, there is currently a lack of high-quality clinical trials in humans directly assessing the effects of tangeretin supplementation for reducing free radical damage or improving health outcomes related to oxidative stress. Most evidence remains at the laboratory or animal research stage. Therefore, while tangeretin is scientifically recognized for its antioxidant activity in experimental settings, its efficacy and safety for this purpose in humans have not yet been established by robust clinical research. The current evidence base justifies a moderate rating of 2 out of 5.

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