Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Resveratrol is a polyphenolic compound found in grapes, red wine, berries, and some plants. Its use to support or treat free radical damage is primarily justified by scientific evidence, though most of the data comes from preclinical and animal studies, with some human studies providing supportive but not conclusive results.

Resveratrol acts as an antioxidant, neutralizing free radicals and reducing oxidative stress in cells. Numerous in vitro (test tube) and animal studies have demonstrated resveratrol’s ability to scavenge reactive oxygen species (ROS) and upregulate endogenous antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione peroxidase. These actions can protect cellular components such as DNA, lipids, and proteins from oxidative damage, which is associated with aging and various diseases.

Some small human clinical trials have also investigated resveratrol supplementation. These studies suggest potential benefits in reducing biomarkers of oxidative stress, especially in populations with metabolic syndrome or at risk for cardiovascular disease. However, the evidence is mixed, and results are not always consistent due to differences in study design, dosages, and bioavailability of resveratrol in humans.

Overall, while there is a strong scientific rationale and a growing body of research, more large-scale and long-term human trials are needed to conclusively determine the efficacy of resveratrol in reducing free radical damage. Thus, the evidence supporting its use for this purpose is moderate, warranting a rating of 3 out of 5.

More about resveratrol
More about Free Radical Damage

Other ingredients used for Free Radical Damage

Other health conditions supported by resveratrol

Products containing resveratrol

Nature's Sunshine Cardio Assurance
Nature's Sunshine Cholester-Reg II
Nature's Sunshine Nattozimes Plus
Nature's Sunshine Solstic Cardio
Nature's Sunshine Super ORAC