Phytofluene is a colorless carotenoid found in tomatoes and other fruits and vegetables. Like other carotenoids, it is known for its antioxidant properties, meaning it can neutralize free radicals—unstable molecules that can damage cells and contribute to aging and various diseases. There is scientific evidence, primarily from in vitro and animal studies, suggesting that phytofluene can act as an antioxidant. These studies indicate that phytofluene is capable of quenching singlet oxygen and scavenging free radicals, thereby potentially reducing oxidative stress in cells.

However, compared to more extensively researched carotenoids such as beta-carotene, lycopene, or lutein, the body of evidence specifically regarding phytofluene’s efficacy in humans is limited. Some research has demonstrated that phytofluene is absorbed in the human body and accumulates in tissues, including the skin, where it may help protect against oxidative damage induced by UV exposure. Nevertheless, most human data are indirect or observational, and there are few clinical trials directly measuring the effects of phytofluene supplementation on free radical damage or related health outcomes.

In summary, while there is scientific rationale and some laboratory evidence for phytofluene’s antioxidant effects, robust clinical validation in humans is lacking, so the strength of evidence is moderate but not high.