Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Melatonin is scientifically validated as an agent that can help mitigate free radical damage due to its potent antioxidant properties. Melatonin is a hormone primarily known for regulating sleep-wake cycles, but extensive in vitro, animal, and human research has demonstrated its ability to directly scavenge a variety of reactive oxygen and nitrogen species, such as hydroxyl radicals, hydrogen peroxide, and peroxynitrite. Additionally, melatonin stimulates the expression and activity of endogenous antioxidant enzymes, including superoxide dismutase, glutathione peroxidase, and catalase. This dual action—direct free radical scavenging and upregulation of antioxidant defenses—makes melatonin particularly effective in reducing oxidative stress. Studies have shown that melatonin can protect lipids, proteins, and DNA from oxidative damage in various tissues. Clinical investigations have reported benefits in contexts associated with elevated oxidative stress, such as neurodegenerative diseases, aging, cardiovascular disorders, and ischemia-reperfusion injury. While most of the strong evidence comes from preclinical models, several human studies support melatonin’s antioxidant effects, especially at higher pharmacological doses. In summary, melatonin’s use to combat free radical damage is strongly supported by mechanistic studies and a growing body of clinical research, justifying its consideration as a scientifically validated antioxidant agent.

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Nature's Sunshine Melatonin Extra