Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mangiferin is a naturally occurring polyphenol primarily found in mangoes (Mangifera indica) and is widely studied for its antioxidant properties. Scientific evidence supports its use in counteracting free radical damage, primarily based on in vitro and animal studies. Mangiferin exhibits a strong ability to scavenge free radicals, inhibit lipid peroxidation, and enhance endogenous antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase. Several studies (e.g., Phytotherapy Research, 2011; Food and Chemical Toxicology, 2007) have demonstrated that mangiferin can protect cells and tissues from oxidative stress induced by various toxicants or pathological conditions. The compound’s antioxidant activity is attributed to its polyphenolic structure, which allows it to donate hydrogen atoms and neutralize reactive oxygen species (ROS).

However, the majority of evidence is preclinical, with relatively few robust human clinical trials. The available human studies are limited in size and scope, though they suggest potential benefits in reducing biomarkers of oxidative stress. No major adverse effects have been reported in the context of these studies. Thus, while there is a credible scientific rationale and preliminary evidence for mangiferin's role in reducing free radical damage, further large-scale clinical studies are warranted to confirm its efficacy in humans.

More about Mangiferin
More about Free Radical Damage

Other ingredients used for Free Radical Damage

Other health conditions supported by Mangiferin

Products containing Mangiferin