Evidence supporting the use of: Gac
For the health condition: Free Radical Damage
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Gac (Momordica cochinchinensis) is a Southeast Asian fruit notable for its exceptionally high content of carotenoids, particularly lycopene and beta-carotene. These compounds are well-recognized antioxidants that can neutralize free radicals—unstable molecules that contribute to cellular damage and oxidative stress. Several scientific studies have analyzed the antioxidant potential of Gac fruit extracts. For example, research published in peer-reviewed journals has shown that Gac fruit oil exhibits significant free radical scavenging ability in vitro, likely due to its rich carotenoid profile (J Food Sci 2006; J Agric Food Chem 2004). Furthermore, dietary carotenoids such as those abundant in Gac are associated in broader literature with reduced markers of oxidative stress and potential protective effects against chronic diseases linked to free radical damage.
While there is a solid rationale and growing experimental evidence supporting the antioxidant properties of Gac, most of the direct research is preclinical (in vitro or animal studies), with relatively few high-quality human trials specifically investigating Gac’s effectiveness against free radical damage in people. Thus, evidence supporting its use is promising but not yet definitive. Traditional use of Gac in Southeast Asian cultures has been more for general health and eye health than specifically for free radical damage. In conclusion, the use of Gac for supporting defense against free radical damage is primarily justified by scientific study, but the strength of clinical evidence is moderate at present.
Other ingredients used for Free Radical Damage
7-hydroxymatairesinol (HMR)acai berry
acetyl l-carnitine
alpha-carotene
alpha-glycosyl isoquercitrin
amino acids
anthocyanins
apricot
ascorbyl palmitate
astaxanthin
astragalus
basil
berry flavor
beta-carotene
beta-tocopherol
bilberry
black currant
black garlic
black tea
blackberry
blueberry
broccoli
brussel sprouts
caffeine
camu camu
catalase
catechins
caterpillar mushroom
cauliflower
chokeberry
chrysin
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cryptoxanthin
turmeric
delta-tocopherol
epigallocatechin gallate (EGCG)
fish protein
flavonols
fruit blend (proprietary)
ginseng
grape
green tea
greens blend (proprietary)
guarana
hesperetin
hesperidin
HMR lignan
l-carnosine
l-cysteine
l-glutathione
l-glycine
lentinula edodes mycelia
lutein
matcha
melatonin
mixed carotenoids
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
oyster mushroom
phenolic acids
phospholipids
pine bark
pyrroloquinoline disodium salt
quercetin
raspberry
reishi mushroom
resveratrol
selenium
spirulina
strawberry
ubiquinol
vegetable blend (proprietary)
vitamin C
vitamin E
whey protein
zinc
papaya
bee pollen
lingzhi
ferulic acid
cistanche
ganoderma
royal jelly
polyphenols
fulvic acid
wheat germ
goji berry
algae
cocoa
1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
Amethoflavone
Ankaflavin
Apigenin
Aronia melanocarpa
Auricularia
Autumn Olive
Antirrhinin
Avocado
Amentoflavone
Acacetin
Allophycocyanin
Alpha-Lipoic Acid
Ascorbigen
Astragaloside
anthocyanidins
Algal protein
Acer Truncatum bunge
anthocyanosides
Argan nut oil
Apocarotenal
Apocynin
Arctiin
Arjunolic acid
Beta-hydroxybutyrate
beta-zeacarotene
Brassica
Bok Choy
Baccosides
BHT (Butylated Hydroxytoluene)
Benfotiamine
Basidiomycota
Betanin
berry
Brazil nut
boysenberry
BHA (butylated hydroxyanisole)
Bioflavonoids
bacoside
Baicalin
Caffeic Acid
Camellia sinensis
Carnosine
Chebulic acid
Cashew
Cichoric acid
Chocolate
Capsorubin
Carnosol
Cupric ascorbate
C-Phycocyanin
Carotene (unspecified)
Chebulinic acid
Crocetin
Canthaxanthin
Crypthecodinium
Capsanthin
Carnosic acid
Dunaliella salina
Dismutase
Delphinidin
Dunaliella
Dehydroascorbic acid
Dumontiaceae
Desoxyrhaponticin
Dragon Fruit
Dibenzo-alpha pyrones
Dihydrolipoic Acid
Diosmetin
Ellagic Acid
Emblicanin
Ecklonia
walnut
Other health conditions supported by Gac
Aging (prevention)Cancer (natural therapy for)
Cancer (prevention)
Free Radical Damage
Inflammation
Skin Care (general)
Ulcers