Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cyanidin-3-glucoside is a type of anthocyanin, a flavonoid found in many fruits and vegetables such as berries, grapes, and purple corn. Its use for supporting or treating free radical damage is primarily justified by scientific evidence. Numerous in vitro and animal studies have shown that cyanidin-3-glucoside exhibits strong antioxidant activity, meaning it can neutralize free radicals and reduce oxidative stress. This is attributed to its chemical structure, which allows it to donate hydrogen atoms or electrons to reactive oxygen species (ROS), thus inhibiting cellular damage.

For example, studies have demonstrated that cyanidin-3-glucoside can protect cells from oxidative damage induced by various stressors, reduce lipid peroxidation, and upregulate endogenous antioxidant defenses such as glutathione and superoxide dismutase. Some limited human studies indicate that consuming anthocyanin-rich foods can reduce markers of oxidative stress in the body, though direct evidence specifically for cyanidin-3-glucoside in humans is still emerging. Overall, the evidence is promising but not yet definitive, especially in the context of clinical outcomes in humans. Thus, the ingredient is scientifically validated for its antioxidant effects at the preclinical level, with moderate but growing evidence for its role in mitigating free radical damage in humans.

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