Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Blue-Green Algae, particularly species like Spirulina and Aphanizomenon flos-aquae, have been studied for their antioxidant properties, which is the primary rationale for their use in supporting or mitigating free radical damage. These algae contain a variety of antioxidant compounds, including phycocyanin, beta-carotene, vitamin E, and phenolic compounds. Laboratory (in vitro) studies have demonstrated that extracts from blue-green algae can scavenge free radicals and reduce markers of oxidative stress. Animal studies have also reported reductions in oxidative damage when subjects were supplemented with blue-green algae. However, the evidence in humans is limited and not robust. Some small-scale clinical trials have shown modest improvements in antioxidant status or reductions in oxidative stress markers after supplementation with spirulina. For example, a few trials in people with type 2 diabetes and other at-risk populations have shown some improvement in blood antioxidant capacity after spirulina supplementation. Despite these findings, the overall quality of evidence is low, with small sample sizes and short durations, and there is a lack of large, well-controlled human studies clearly demonstrating a meaningful reduction in free radical damage or associated health outcomes. In summary, while there is a scientific basis for the use of blue-green algae against free radical damage, the strength of the evidence is modest and mostly preclinical, warranting a rating of 2 out of 5.

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