Evidence supporting the use of: Benfotiamine
For the health condition: Free Radical Damage
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Benfotiamine is a synthetic derivative of thiamine (vitamin B1) that has been studied for its potential to mitigate free radical damage, particularly in the context of diabetes and related complications. Scientific interest in benfotiamine centers around its ability to increase thiamine levels more effectively than standard thiamine supplements and to modulate pathways involved in oxidative stress and advanced glycation end-product (AGE) formation. Preclinical studies suggest that benfotiamine can reduce oxidative stress markers and inhibit the formation of AGEs, which are known to contribute to free radical production and tissue damage, particularly in hyperglycemic states.
Some small clinical trials have reported that benfotiamine supplementation improves markers of oxidative stress and endothelial function in patients with diabetes. For instance, studies have shown that benfotiamine can decrease plasma levels of AGEs and improve antioxidant capacity. However, these studies are generally limited in scope, sample size, and duration. There is a lack of large-scale, long-term clinical trials directly demonstrating that benfotiamine reduces clinical endpoints related to free radical damage in humans.
Overall, while there is some mechanistic and preliminary clinical evidence suggesting that benfotiamine may help reduce free radical damage, especially in diabetic populations, the evidence is not robust or conclusive. Therefore, its use for this purpose is rated as “2” for evidence strength, indicating limited but present scientific support.
Other ingredients used for Free Radical Damage
7-hydroxymatairesinol (HMR)acai berry
acetyl l-carnitine
alpha-carotene
alpha-glycosyl isoquercitrin
amino acids
anthocyanins
apricot
ascorbyl palmitate
astaxanthin
astragalus
basil
berry flavor
beta-carotene
beta-tocopherol
bilberry
black currant
black garlic
black tea
blackberry
blueberry
broccoli
brussel sprouts
caffeine
camu camu
catalase
catechins
caterpillar mushroom
cauliflower
chokeberry
chrysin
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cryptoxanthin
turmeric
delta-tocopherol
epigallocatechin gallate (EGCG)
fish protein
flavonols
fruit blend (proprietary)
ginseng
grape
green tea
greens blend (proprietary)
guarana
hesperetin
hesperidin
HMR lignan
l-carnosine
l-cysteine
l-glutathione
l-glycine
lentinula edodes mycelia
lutein
matcha
melatonin
mixed carotenoids
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
oyster mushroom
phenolic acids
phospholipids
pine bark
pyrroloquinoline disodium salt
quercetin
raspberry
reishi mushroom
resveratrol
selenium
spirulina
strawberry
ubiquinol
vegetable blend (proprietary)
vitamin C
vitamin E
whey protein
zinc
papaya
bee pollen
lingzhi
ferulic acid
cistanche
ganoderma
royal jelly
polyphenols
fulvic acid
wheat germ
goji berry
algae
cocoa
1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
Amethoflavone
Ankaflavin
Apigenin
Aronia melanocarpa
Auricularia
Autumn Olive
Antirrhinin
Avocado
Amentoflavone
Acacetin
Allophycocyanin
Alpha-Lipoic Acid
Ascorbigen
Astragaloside
anthocyanidins
Algal protein
Acer Truncatum bunge
anthocyanosides
Argan nut oil
Apocarotenal
Apocynin
Arctiin
Arjunolic acid
Beta-hydroxybutyrate
beta-zeacarotene
Brassica
Bok Choy
Baccosides
BHT (Butylated Hydroxytoluene)
Benfotiamine
Basidiomycota
Betanin
berry
Brazil nut
boysenberry
BHA (butylated hydroxyanisole)
Bioflavonoids
bacoside
Baicalin
Caffeic Acid
Camellia sinensis
Carnosine
Chebulic acid
Cashew
Cichoric acid
Chocolate
Capsorubin
Carnosol
Cupric ascorbate
C-Phycocyanin
Carotene (unspecified)
Chebulinic acid
Crocetin
Canthaxanthin
Crypthecodinium
Capsanthin
Carnosic acid
Dunaliella salina
Dismutase
Delphinidin
Dunaliella
Dehydroascorbic acid
Dumontiaceae
Desoxyrhaponticin
Dragon Fruit
Dibenzo-alpha pyrones
Dihydrolipoic Acid
Diosmetin
epicatechin
Ellagic Acid
Ergothioneine
Emblicanin
Erythorbic acid
Ethylgallate
Eriodictyol
Ecklonia
Fucoidan
Flavin mononucleotide
Fatty acids
Furanosterols
Flavanones
Flavoglycosides
Flavans
Flavonones
Flavones
Ginsenosides
Glucan peptides
Gac
Gamma-Glutamylcysteine
Garcinone C
Garcinone E
Glutathione
Gamma-carotene
walnut
Other health conditions supported by Benfotiamine
Alzheimer's DiseaseBurning Feet or Hands
Cardiovascular Disease
Diabetes
Diabetic Retinopathy
Free Radical Damage
Inflammation
Nerve Damage
Pain (general remedies for)
Peripheral Neuropathy
