Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Amino acids have scientific validation for their role in supporting the body against free radical damage, though the direct evidence is moderate rather than robust. Amino acids such as cysteine, glutamine, and glycine are precursors for the synthesis of glutathione, one of the body's most important intracellular antioxidants. Glutathione neutralizes reactive oxygen species (ROS) and helps repair oxidative damage in cells. Studies indicate that supplementation with these amino acids can boost glutathione levels, especially in situations of increased oxidative stress, such as illness, intense physical activity, or aging.

Furthermore, some amino acids, like histidine, possess direct free radical scavenging properties due to their chemical structure. Clinical and animal studies have shown that amino acid supplementation can reduce biomarkers of oxidative damage, although most research involves specific amino acids rather than general amino acid blends.

Overall, while amino acids are not typically marketed as standalone "antioxidants," their role as building blocks for antioxidant molecules and their contribution to the body’s defense mechanisms against free radicals is well established. More high-quality human trials are needed to define optimal doses and clinical outcomes, but the biochemical rationale for their use to support antioxidant defenses is strong.

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