Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Amino acid blends or complexes are sometimes used to support the body's defense against free radical damage, based on their roles as precursors to endogenous antioxidants. Scientific evidence supporting this use is limited but present. Certain amino acids, such as cysteine, glycine, and glutamate, are essential for the synthesis of glutathione, one of the body’s most important intracellular antioxidants. Glutathione plays a critical role in neutralizing free radicals and maintaining cellular redox balance. Some clinical and preclinical studies suggest that supplementation with specific amino acids or their blends can boost glutathione levels and improve antioxidant capacity, particularly in populations under oxidative stress (e.g., athletes, elderly, or patients with certain diseases).

However, the evidence for the effectiveness of generic "amino acid blends/complexes" in treating or preventing free radical damage in the general population is not robust. Most studies focus on specific amino acids rather than broad, undefined blends. Furthermore, the translation of increased glutathione synthesis from supplementation to meaningful clinical outcomes remains to be fully established. While there is a scientific rationale for the use of certain amino acids to support antioxidant defenses, large-scale, high-quality clinical trials are lacking. Therefore, the current level of evidence is modest and does not support widespread use for this indication without further research.

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