Synopsis

Source of validity: Scientific
Rating (out of 5): 3

American Ginseng (Panax quinquefolius) has been studied for its antioxidant properties, which are relevant to the management of free radical damage. Laboratory (in vitro) and animal studies have demonstrated that extracts from American ginseng roots contain ginsenosides and other phytochemicals that can scavenge free radicals and reduce oxidative stress. These compounds appear to enhance the activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase, and decrease markers of lipid peroxidation. While these findings provide a scientific rationale for its use in counteracting free radical damage, the majority of evidence comes from preclinical research, with only limited human trials available. Some small clinical studies suggest that American ginseng supplementation may reduce markers of oxidative stress in humans, but results are preliminary and not yet conclusive. Therefore, while there is scientific evidence supporting the antioxidant and free radical-scavenging potential of American ginseng, the clinical relevance and efficacy for preventing or treating oxidative stress-related diseases in humans require further investigation.

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