Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Osthole is a natural coumarin compound primarily isolated from the plant Cnidium monnieri. In recent years, its potential role in treating or supporting fibrosis has been explored in scientific research, though primarily in preclinical (in vitro and animal) models. Several studies have reported that osthole exhibits anti-fibrotic effects in models of liver, lung, and renal fibrosis. The proposed mechanisms include inhibition of the TGF-β1/Smad signaling pathway, reduction of collagen deposition, and suppression of fibroblast activation and proliferation. For example, a 2018 study published in the journal Phytomedicine found that osthole attenuated liver fibrosis in mice by modulating oxidative stress and inhibiting hepatic stellate cell activation. Other studies have reported similar findings in experimental models of pulmonary and renal fibrosis.

However, it is important to note that the evidence for osthole’s efficacy in fibrosis remains at the experimental stage; there are no published clinical trials in humans specifically investigating its use for fibrosis. While the mechanistic and animal data are promising, translation to human therapeutic potential is unproven and further research, especially well-designed clinical trials, is required. Therefore, the use of osthole for fibrosis is justified by preliminary scientific evidence but not by tradition or robust clinical proof.

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