Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ligustilide is a phthalide compound predominantly found in traditional Chinese medicinal herbs such as Angelica sinensis (Dong Quai) and Ligusticum chuanxiong (Chuanxiong). Recent scientific studies, primarily in vitro and in animal models, have started to explore Ligustilide’s potential role in modulating fibrosis. Fibrosis is characterized by excessive deposition of extracellular matrix components, leading to tissue scarring and organ dysfunction. Preclinical studies have demonstrated that Ligustilide can exert anti-fibrotic effects by inhibiting the activation and proliferation of fibroblasts, suppressing the TGF-β/Smad signaling pathway, and reducing the expression of pro-fibrotic cytokines and extracellular matrix proteins. For example, research has shown that Ligustilide attenuates hepatic and renal fibrosis in rodent models, suggesting potential therapeutic benefits.

However, the current evidence is limited to preclinical studies; there are no large-scale clinical trials or substantial human data confirming Ligustilide’s efficacy or safety in treating fibrosis in humans. Thus, while there is a scientific rationale and preliminary validation for its use in fibrotic conditions, the overall quality and quantity of evidence remain limited. Further research, especially well-designed clinical trials, is necessary to establish Ligustilide’s clinical effectiveness and safety profile for fibrosis treatment.

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