Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hyperoside is a flavonoid glycoside found in various medicinal plants, such as Hypericum perforatum and Crataegus species. Its use in the context of fibrosis is supported by emerging preclinical evidence, primarily from in vitro and animal studies. Research indicates that hyperoside may exert anti-fibrotic effects through several mechanisms, such as inhibiting the TGF-β1/Smad signaling pathway, reducing oxidative stress, and suppressing inflammatory responses. For instance, studies in animal models of liver fibrosis have shown that hyperoside can attenuate collagen deposition and decrease levels of fibrosis markers (e.g., α-SMA, collagen I). Similar anti-fibrotic activities have been observed in models of renal and pulmonary fibrosis.

Despite these promising findings, there are currently no robust clinical trials or substantial human data confirming its efficacy or safety for treating fibrosis in patients. Most evidence remains preclinical, and the translation to clinical practice is still speculative. Therefore, while there is some scientific rationale and experimental support, the overall evidence level is low (rated 2/5), and hyperoside cannot be considered an established or evidence-based therapy for fibrosis at this time.

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