Evidence supporting the use of: Cordyceps
For the health condition: Fibrosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cordyceps, a genus of parasitic fungi, has been used in traditional Chinese medicine for centuries, primarily to boost vitality and support lung and kidney health. More recently, scientific studies have explored its potential in treating fibrosis, particularly pulmonary fibrosis. Preclinical research suggests that extracts from Cordyceps species, such as Cordyceps sinensis and Cordyceps militaris, possess anti-fibrotic effects in animal models. These effects are thought to be mediated through the modulation of inflammatory pathways, reduction of oxidative stress, and inhibition of fibroblast proliferation and collagen deposition—key processes in the development of fibrosis.

Several studies in cell cultures and rodents have reported that Cordyceps or its bioactive components (like cordycepin and polysaccharides) can decrease markers of fibrosis and improve tissue structure in models of lung, liver, and kidney fibrosis. However, there is a lack of large-scale, high-quality clinical trials in humans. Most available evidence is limited to laboratory and animal studies, meaning the translation to effective human treatments remains uncertain. Thus, while there is scientific interest and some supportive preclinical data, the overall strength of evidence is still preliminary (rated 2/5). Cordyceps should not be considered a proven treatment for fibrosis, but ongoing research may further clarify its role in the future.

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