Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Astragalin is a natural flavonoid compound found in various medicinal plants such as Astragalus and Kaempferia galanga. Its use in supporting or treating fibrosis is primarily supported by preclinical scientific research rather than traditional medicine. Several in vitro and animal studies have shown that Astragalin possesses anti-inflammatory, antioxidant, and anti-fibrotic properties. For example, studies have demonstrated that Astragalin can inhibit the activation of hepatic stellate cells (a key event in liver fibrosis) and reduce the expression of fibrotic markers such as α-SMA, TGF-β1, and collagen in animal models of liver fibrosis. The proposed mechanisms involve suppression of the TGF-β/Smad signaling pathway and reduction of oxidative stress and pro-inflammatory cytokines.

However, despite these promising preclinical results, there is currently a lack of robust clinical evidence in humans. No large-scale or well-designed clinical trials have examined Astragalin’s efficacy or safety in treating fibrosis in humans. Its use is therefore based on early-stage scientific validation, and not broadly recommended in clinical practice for fibrosis at this time. The evidence rating is moderate for preclinical studies (rated 2 out of 5), but insufficient for clinical application.

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