Evidence supporting the use of: Vitamin D3
For the health condition: Fibromyalgia Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 has gained attention in the management of Fibromyalgia Syndrome (FMS), primarily due to the observed association between low vitamin D levels and chronic musculoskeletal pain. Several observational studies have reported that a significant proportion of fibromyalgia patients exhibit vitamin D deficiency. This has led to the hypothesis that supplementation could alleviate some symptoms, particularly pain and fatigue. Small randomized controlled trials (RCTs) have provided mixed results: some report modest improvements in pain and quality of life with vitamin D3 supplementation in deficient individuals, while others show no significant benefit compared to placebo. A 2014 meta-analysis (Yong WC et al., “Vitamin D supplementation for chronic widespread pain in adults,” Cochrane Review) found insufficient and low-quality evidence to recommend vitamin D for fibromyalgia, although it did not rule out benefit for subgroups with clear deficiency. Current clinical guidelines do not endorse vitamin D3 as a primary treatment for fibromyalgia, but suggest that correcting deficiency is reasonable. Overall, the evidence base is weak (rated as 2/5): while there are plausible mechanisms and some small studies suggesting benefit, high-quality, large-scale RCTs are lacking and the effect size seems modest at best. In practice, vitamin D3 supplementation is often considered as an adjunct, particularly when laboratory testing confirms deficiency, but it is not a standalone therapy for FMS.

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