Evidence supporting the use of: Methylsulfonylmethane (MSM)
For the health condition: Fibromyalgia Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Methylsulfonylmethane (MSM) is a sulfur-containing compound commonly found in dietary supplements promoted for joint health and chronic pain conditions, including fibromyalgia. The rationale for MSM use in fibromyalgia is primarily based on its purported anti-inflammatory and antioxidant properties, which could theoretically alleviate some symptoms of the syndrome, such as muscle pain and fatigue. Scientifically, the evidence is limited but not entirely absent. A small double-blind, placebo-controlled trial published in 2011 investigated the effects of MSM in patients with fibromyalgia. The study reported improvements in certain symptoms, such as pain and physical function, after 12 weeks of MSM supplementation. However, the sample size was small, and the study design had limitations, including a lack of long-term follow-up and potential bias. Systematic reviews on MSM for chronic pain conditions frequently note the paucity of high-quality studies specific to fibromyalgia, and larger, more rigorous trials are needed to confirm its efficacy and safety. While MSM is generally well-tolerated, its use for fibromyalgia is not supported by strong clinical evidence, and most major guidelines for fibromyalgia management do not recommend it. In summary, while there is some preliminary scientific interest and a small amount of direct evidence, the overall support for MSM as a treatment for fibromyalgia is weak, and its use should be approached with caution.

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