Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Melatonin has a scientific basis for its use in supporting or treating Fibromyalgia Syndrome (FMS), although the evidence is moderate and not definitive. Fibromyalgia is characterized by chronic, widespread pain, sleep disturbances, and fatigue. Sleep dysfunction is a key component of fibromyalgia, and melatonin—a hormone produced by the pineal gland that regulates circadian rhythms and sleep—has been explored as a therapeutic option. Several small randomized controlled trials and pilot studies have investigated melatonin supplementation in patients with fibromyalgia. These studies generally report improvements in sleep quality, reductions in pain, and better overall quality of life compared to placebo. Proposed mechanisms include melatonin’s role in restoring circadian rhythm, its analgesic properties (possibly via modulation of neurotransmitters and anti-inflammatory effects), and its potential to enhance the efficacy of other treatments such as antidepressants.

However, the quality and size of the existing studies are limited, with short durations and small sample sizes. Systematic reviews (e.g., a 2022 review in Clinical Rheumatology) conclude that while melatonin shows promise, more robust, large-scale studies are required before it can be recommended as a standard therapy for fibromyalgia. Nevertheless, its favorable safety profile and the centrality of sleep problems in FMS management justify cautious consideration as an adjunctive therapy.

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Nature's Sunshine Melatonin Extra