Evidence supporting the use of: Indole-3-Carbinol (I3C)
For the health condition: Fibroids (uterine)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Indole-3-Carbinol (I3C) is a compound derived from cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts. Its use for uterine fibroids is supported by a limited but growing body of scientific evidence, primarily from laboratory and animal studies. The rationale for using I3C in the context of fibroids centers on its ability to modulate estrogen metabolism. Fibroids are estrogen-sensitive tumors, and I3C is known to shift estrogen metabolism towards less proliferative metabolites, potentially reducing the growth stimulus for fibroid tissue.

Several in vitro and animal studies have demonstrated that I3C and its metabolite, diindolylmethane (DIM), can inhibit the proliferation of uterine fibroid cells and induce apoptosis. For example, a 2013 study published in Reproductive Sciences showed that I3C suppressed proliferation and induced apoptosis in human uterine leiomyoma cells. However, high-quality human clinical trials are lacking. Most clinical evidence for I3C focuses on hormone-related conditions such as cervical dysplasia, with only anecdotal or preliminary data for fibroids.

In summary, while there is a plausible scientific mechanism and some preclinical evidence supporting the use of I3C for uterine fibroids, robust clinical data in humans are currently insufficient. Therefore, the evidence rating is 2 out of 5, reflecting limited but suggestive scientific support. Individuals considering I3C for fibroids should consult healthcare professionals, as further research is needed to confirm its efficacy and safety in this context.

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