Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Indole-3-carbinol (I3C) is a compound found in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts. Its use for uterine fibroids is supported by some preliminary scientific evidence, though the quality and quantity of data remain limited. The rationale for its use is based on its ability to modulate estrogen metabolism. Since uterine fibroids are estrogen-sensitive benign tumors of the uterus, compounds that influence estrogen pathways are of interest for potential therapeutic use.

Several in vitro and animal studies have demonstrated that I3C can alter estrogen metabolism, favoring the production of less proliferative estrogen metabolites. This shift may theoretically reduce the estrogen-driven growth of fibroids. Additionally, a small number of clinical studies and case reports have suggested that I3C supplementation may decrease fibroid size or slow their progression. However, these studies often lack rigorous design, have small sample sizes, or are not placebo-controlled.

Current scientific consensus does not elevate I3C to a first-line treatment for uterine fibroids due to the limited human evidence and lack of large, high-quality clinical trials. Nonetheless, its biological plausibility and early findings justify further investigation. Patients interested in I3C for fibroid management should consult healthcare providers and not rely solely on supplementation in place of established treatments.

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Nature's Sunshine Indole-3-Carbinol