Evidence supporting the use of: Inositol
For the body system: Female Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Inositol, particularly myo-inositol, has scientific validation for supporting the female reproductive system, especially in the context of polycystic ovary syndrome (PCOS). Multiple randomized controlled trials and meta-analyses have demonstrated that myo-inositol supplementation can improve ovarian function, restore ovulation, and enhance insulin sensitivity in women with PCOS. These effects are believed to be due to inositol's role as a secondary messenger in insulin signaling pathways, helping to reduce insulin resistance—a key factor in PCOS-related reproductive dysfunction. Additionally, inositol has been shown to improve hormonal profiles (including reducing elevated testosterone) and menstrual cyclicity. Some studies also suggest benefits for oocyte quality in women undergoing assisted reproductive technologies.

The level of evidence is strongest for inositol’s use in women with PCOS, where guidelines from organizations such as the International Evidence-Based Guideline for the Assessment and Management of PCOS (2018) recommend considering inositol as a supplement for metabolic and reproductive aspects of the syndrome. However, evidence is more limited or inconclusive for other reproductive conditions or for use in women without PCOS. Overall, inositol is not only traditionally used but is supported by a robust and growing body of scientific research for specific female reproductive health concerns.

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Other ingredients that support Female Reproductive System

7-hydroxymatairesinol (HMR)
amino acids
ashwagandha
basil
black cohosh
borage oil
broccoli
chaste tree
turmeric
d-alpha tocopherol
damiana
dandelion
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
eleuthero
evening primrose oil
fennel
fenugreek
flaxseed
folate
gamma linolenic acid (GLA)
genistein
ginger
goldenseal
hibiscus
HMR lignan
Indian tinospora
indole-3-carbinol
inositol
jujube
lactobacillus acidophilus
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus jensenii
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lignans
linoleic acid (LA)
maca
marine lipid
motherwort
nettle
omega-3 fatty acids
raspberry
rose oil
saffron
selenium
soybean
spearmint leaf
tribulus
vitamin B
vitamin B6
vitamin E
wild yam
red clover
squawvine
mugwort
anise
caesalpinia crista
rubia cordifolia
blessed thistle
peony
lingzhi
lingusticum wallichii
yarrow
yarrow
dioscorea
dodder
royal jelly
Equol (proprietary)
guelder rose
trace minerals
anemarrhena asphodeloides
shepherd's purse
wood betony
herbal blend (proprietary)
soy isoflavones
27-deoxyactein
25-d-spirosta-3, 5-diene
8-Prenylnaringenin
Angelica
Anamu
AHCC
Alchemilla
Aletris
Anserina
Anemone
Agnuside
Ashoka
Abuta
Animal protein
Betony
Blue Cohosh
Bugbane
Bethroot
Barbasco
Belamcanda
Bird's nest
Calochortus
Cohosh
Clary sage
Cnidium
Cynomorium
Cramp Bark
Chinese Pond Turtle
Chlorophytum
Casticin
Ceylon Leadwort
Crinum latifolium
DHEA
Daidzein
Dong Quai
Diosgenin
Date
Egg
Erythrina
Evening Primrose Oil
Estrogen
Folic Acid
Fo-Ti
Furostanols
formononetin
Fatty acids
False Unicorn Root
Ginsenosides
Goat's rue
Giant Trillium
Golden Ragwort
Isoflavones
jasmine
Pennyroyal
Rose
Soy Protein
Vervain