Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Indole-3-carbinol (I3C) is a compound naturally found in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts. Its use to support the female reproductive system, particularly in the context of estrogen metabolism and hormonal balance, is supported by a moderate body of scientific evidence. Several clinical and preclinical studies have shown that I3C can influence estrogen metabolism by promoting the formation of less potent estrogen metabolites, such as 2-hydroxyestrone, over more potent forms like 16α-hydroxyestrone. This shift in estrogen metabolism is hypothesized to reduce the risk of estrogen-sensitive conditions, including certain types of breast and cervical dysplasia.

Randomized controlled trials and pilot studies have demonstrated that I3C supplementation may induce regression of cervical intraepithelial neoplasia (CIN), a precancerous lesion of the cervix, and may be beneficial in conditions like recurrent respiratory papillomatosis, which is also related to HPV infection. However, while these findings are promising, the number of high-quality, large-scale human trials is limited. Most evidence comes from small clinical trials or mechanistic studies.

Overall, the use of I3C for female reproductive health is backed by some scientific validation, especially in the context of estrogen metabolism and cervical health, but further research is needed to fully establish its efficacy and safety for widespread use in this context.

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Nature's Sunshine Indole-3-Carbinol