Evidence supporting the use of: Evening primrose oil
For the body system: Female Reproductive System

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Evening primrose oil (EPO) has a long history of traditional use for supporting the female reproductive system, particularly for conditions such as premenstrual syndrome (PMS), breast pain (mastalgia), and menopausal symptoms. The oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid thought to influence prostaglandin production and, therefore, hormone regulation and inflammation. Many women have historically used EPO as a natural remedy to alleviate symptoms like breast tenderness, mood swings, and menstrual cramps.

However, when examining the scientific evidence, support for these uses is limited and inconsistent. Reviews of clinical trials have found that EPO is no more effective than placebo for PMS or mastalgia in most well-conducted studies. Multiple systematic reviews, including Cochrane analyses, generally conclude there is little reliable evidence to recommend EPO for these reproductive health concerns. Some small studies have suggested minor benefits, but these are often offset by methodological flaws, small sample sizes, or lack of replication.

As such, evening primrose oil’s reputation for supporting the female reproductive system rests largely on tradition and anecdotal reports rather than robust scientific validation. While it is widely used for this purpose, consumers should be aware that current scientific research does not strongly support its effectiveness for reproductive or hormonal health issues.

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7-hydroxymatairesinol (HMR)
amino acids
ashwagandha
basil
black cohosh
borage oil
broccoli
chaste tree
turmeric
d-alpha tocopherol
damiana
dandelion
DHEA (dehydroepiandrosterone)
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eleuthero
evening primrose oil
fennel
fenugreek
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folate
gamma linolenic acid (GLA)
genistein
ginger
goldenseal
hibiscus
HMR lignan
Indian tinospora
indole-3-carbinol
inositol
jujube
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lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus jensenii
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lignans
linoleic acid (LA)
maca
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motherwort
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omega-3 fatty acids
raspberry
rose oil
saffron
selenium
soybean
spearmint leaf
tribulus
vitamin B
vitamin B6
vitamin E
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caesalpinia crista
rubia cordifolia
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peony
lingzhi
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yarrow
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dioscorea
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anemarrhena asphodeloides
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wood betony
herbal blend (proprietary)
soy isoflavones
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AHCC
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Betony
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Bugbane
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Chlorophytum
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