Synopsis

Source of validity: Traditional
Rating (out of 5): 2

27-deoxyactein is a triterpene glycoside primarily found in the root of Actaea racemosa, commonly known as black cohosh. The use of black cohosh to support the female reproductive system—particularly for alleviating menopausal symptoms such as hot flashes, night sweats, and mood disturbances—has a long history in traditional North American indigenous medicine, as well as in European herbal practice. The primary focus has been on the whole root extract rather than isolated 27-deoxyactein, but this compound is considered one of the key active constituents contributing to the plant’s effects.

While there is some scientific research on black cohosh extracts in the context of menopause, direct evidence linking 27-deoxyactein specifically to support of the female reproductive system is limited. Most clinical studies use standardized extracts containing a mixture of triterpene glycosides, including 27-deoxyactein, but do not isolate the effects of this single compound. Systematic reviews have found mixed results on the efficacy of black cohosh for menopausal symptoms, and regulatory agencies such as the European Medicines Agency acknowledge its traditional use while noting that evidence for clinical effectiveness is not robust. In summary, the use of 27-deoxyactein for the female reproductive system is primarily justified by traditional use, with limited scientific validation specific to this compound.

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