Evidence supporting the use of: Vitamin E
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E has been studied as a treatment for nonalcoholic fatty liver disease (NAFLD), especially its more severe form, nonalcoholic steatohepatitis (NASH). The rationale for its use is based on its antioxidant properties: oxidative stress is considered a key factor in the progression of fatty liver disease. Several randomized controlled trials, most notably the PIVENS trial (Sanyal et al., 2010, New England Journal of Medicine), have shown that high-dose vitamin E (800 IU/day) improves liver histology in non-diabetic adults with biopsy-confirmed NASH. Improvements included reduced liver inflammation, steatosis, and ballooning, but not fibrosis.

Based on this evidence, authoritative guidelines such as those from the American Association for the Study of Liver Diseases (AASLD) recommend vitamin E as a first-line therapy for non-diabetic adults with biopsy-proven NASH. However, its use is not recommended for patients with diabetes, cirrhosis, or children, largely due to insufficient safety data and potential risks. Some studies have raised concerns about long-term high-dose vitamin E supplementation, including potential increased risks of prostate cancer and all-cause mortality, though these findings remain debated.

In summary, vitamin E is scientifically validated for certain patients with NASH, with moderate strength of evidence (rated 3/5), but it is not universally recommended for all fatty liver disease cases. Ongoing research will further clarify its role and safety profile.

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Other ingredients used for Fatty Liver Disease

Akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
Bifidobacterium bifidum
Bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
L-glutathione
L-methionine
L-taurine
lecithin
licorice root
liquid liver fractions
Marine lipid
medium chain triglycerides (MCT)
Milk thistle
Naringin
Niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic compounds
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
Trans-pterostilbene
tributyrin
Trimethylglycine (TMG)
Triphala
Urolithin A
vitamin C
vitamin E
seaweed
Mulberry
Zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
Enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
Morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
Algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
arjuna
apigenin
Aronia melanocarpa
Antrodia camphorata
avocado
Ascophyllum nodosum
Acacetin
alpha-lipoic acid
astragaloside
Adzuki bean
ampelopsin
Algal protein
Alisma
arabinoxylan
argan nut oil
Anemarrhena
Alpha methyl tetradecylthioacetic acid
apocynin
Arjunolic acid
borotutu
brutieridin
Brown Algae
Brassica
Berberis (unspecified)
baicalein
Blakeslea trispora
betanin
Bifidobacteria
bile acid
baicalin
carqueja
chebulic acid
camelina oil
coriander
chlorogenic acid
cynarin
cruciferous
Chitin-Glucan Complex
Caulerpa okamurae
copalchi
Curcuma
corilagin
crocetin
cynaropicrin
corosolic acid
carnosic acid
diallyl sulfide
danshen
dihydromyricetin
DL-Methionine
decursin
D-Pinitol
diosgenin
dithiolthiones
epicatechin
eriocitrin
ergothioneine
erythrodiol
eicosapentaenoic acid
Eucommia ulmoides
fucoidan
fiber
fucosterol
fatty acids
flavanones
fucoxanthin
flavonolignan
Glutathione
hydroxycinnamic acid
hydroxytyrosol
isosilybin
Jaboticaba
Jurubeba
Job\'s tears
Kefir
Lycium
Lactobacillus plantarum
limonoid
Legume protein
mangiferin
Myricetin
Monounsaturated fat
Marine fat
Naringenin
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oolong tea
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Oxymatrine
ornithine L-aspartic acid
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Phellodendron
Puerarin
phlorizin
Phaeophyceae
Pinitol
phlorotannins
Polydatin
Phthalides
pu-er tea
purple tea
punicalagins
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rapeseed oil
rhubarb
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Schizochytrium
Silybin
Syringic acid
Salvianolic acid
Salacia
Schisandrins
Silydianin
Silychristin
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