Evidence supporting the use of: Vitamin E
For the health condition: Fatty Liver Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E has been studied as a treatment for nonalcoholic fatty liver disease (NAFLD), especially its more severe form, nonalcoholic steatohepatitis (NASH). The rationale for its use is based on its antioxidant properties: oxidative stress is considered a key factor in the progression of fatty liver disease. Several randomized controlled trials, most notably the PIVENS trial (Sanyal et al., 2010, New England Journal of Medicine), have shown that high-dose vitamin E (800 IU/day) improves liver histology in non-diabetic adults with biopsy-confirmed NASH. Improvements included reduced liver inflammation, steatosis, and ballooning, but not fibrosis.

Based on this evidence, authoritative guidelines such as those from the American Association for the Study of Liver Diseases (AASLD) recommend vitamin E as a first-line therapy for non-diabetic adults with biopsy-proven NASH. However, its use is not recommended for patients with diabetes, cirrhosis, or children, largely due to insufficient safety data and potential risks. Some studies have raised concerns about long-term high-dose vitamin E supplementation, including potential increased risks of prostate cancer and all-cause mortality, though these findings remain debated.

In summary, vitamin E is scientifically validated for certain patients with NASH, with moderate strength of evidence (rated 3/5), but it is not universally recommended for all fatty liver disease cases. Ongoing research will further clarify its role and safety profile.

More about vitamin E
More about Fatty Liver Disease

Other ingredients used for Fatty Liver Disease

4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Acacetin
Adzuki bean
Akkermansia muciniphila
Algae
algal oil
Algal protein
Alisma
Alpha methyl tetradecylthioacetic acid
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
alpha-lipoic acid
AMP-activated protein kinase (AMPK)
ampelopsin
Anemarrhena
anemarrhena asphodeloides
anthocyanins
Antrodia camphorata
apigenin
apocynin
arabinoxylan
argan nut oil
arjun tree
arjuna
Arjunolic acid
Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
astaxanthin
astragaloside
avocado
baicalein
baicalin
banaba
barberry
barley
beet
berberine
Berberis (unspecified)
betanin
Bifidobacteria
Bifidobacterium bifidum
Bifidobacterium longum
bile acid
black garlic
Blakeslea trispora
borotutu
branched-chain amino acids
Brassica
Brown Algae
brutieridin
butyrate triglyceride
butyric acid
camelina oil
carnosic acid
carqueja
catechins
caterpillar mushroom
Caulerpa okamurae
cauliflower
chebulic acid
chia seed
chicory
Chitin-Glucan Complex
chlorella
chlorogenic acid
chokeberry
choline
coix
conjugated linoleic acid (CLA)
copalchi
coriander
corilagin
corosolic acid
crocetin
cruciferous
Curcuma
curcumin
cyclodextrin
cynarin
cynaropicrin
D-Pinitol
dandelion
danshen
decursin
diallyl disulfide (DADS)
diallyl sulfide
dihydromyricetin
diosgenin
dithiolthiones
DL-Methionine
eicosapentaenoic acid
Enicostemma littorale
EPA (eicosapentaenoic acid)
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
erythrodiol
Eucommia ulmoides
fatty acids
fenugreek
ferulic acid
fiber
fiber blend (proprietary)
fish oil
fish protein
flavanones
flavonolignan
flavonols
flaxseed
fucoidan
fucosterol
fucoxanthin
ganoderma
ginger
Glutathione
grape
hesperetin
hydroxycinnamic acid
hydroxytyrosol
isosilybin
Jaboticaba
jiaogulan
Job\'s tears
Jurubeba
Kefir
kelp
l-carnitine
L-glutathione
L-methionine
L-taurine
Lactobacillus plantarum
lecithin
Legume protein
licorice root
limonoid
lingzhi
liquid liver fractions
Lycium
mangiferin
Marine fat
Marine lipid
medium chain triglycerides (MCT)
Milk thistle
Monounsaturated fat
Morus
Mulberry
Myricetin
Naringenin
Naringin
Niacin (vitamin B3)
nicotinamide riboside
nopal
oleanolic acid
oleic acid
Oleoylethanolamide
Oleuropein
Oligosaccharides
olive
omega-3 fatty acids
omega-9 fatty acids
oolong tea
ornithine L-aspartic acid
Osthole
Oxymatrine
palmitoleic acid
perilla
Phaeophyceae
Phellodendron
phenolic compounds
phlorizin
phlorotannins
phosphatidylcholine
phospholipids
Phthalides
picrorhiza kurroa
Pinitol
Polydatin
polyphenols
prebiotic blend (proprietary)
psyllium
pu-er tea
Puerarin
punarnava
punicalagins
purple tea
rapeseed oil
Rebaudioside
reishi mushroom
resveratrol
rhubarb
S-allylcysteine
Salacia
Salvianolic acid
Schisandrins
Schizochytrium
Schizochytrium Oil
seaweed
sesame
Sesamin
Silybin
Silychristin
Silydianin
silymarin
Sinensetin
spirulina
Syringic acid
Tangeretin
Tanshinone
Taurine
Taxifolin
Tetradecylthioacetic acid
Theabrownin
Thistle
tocotrienols
Trans-pterostilbene
Trehalose
tributyrin
Trimethylglycine (TMG)
Triphala
turmeric
Tyrosol
Urolithin A
Ursolic Acid
Varuna
vitamin C
vitamin E
Wakame
Walnut
Wax Gourd
Yacon
Yin Chen
Zinc
Zucchini
β-nicotinamide mononucleotide (NMN)