Evidence supporting the use of: Schizochytrium Oil
For the health condition: Fatty Liver Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Schizochytrium oil is a rich source of the omega-3 fatty acid docosahexaenoic acid (DHA). There is a growing body of scientific evidence suggesting that omega-3 fatty acids, particularly DHA and eicosapentaenoic acid (EPA), can help improve liver fat content and markers of liver health in individuals with non-alcoholic fatty liver disease (NAFLD). Most studies have focused on fish oil-derived omega-3s, but Schizochytrium oil is a plant-based, microalgae-derived alternative that provides high levels of DHA.
Several animal and small human studies have shown that DHA supplementation from Schizochytrium oil or similar algal oils can reduce hepatic fat accumulation, improve lipid profiles, and decrease inflammation associated with fatty liver disease. For example, a 2018 randomized controlled trial found that DHA-rich algal oil supplementation reduced liver fat and improved liver enzymes in subjects with NAFLD. Preclinical studies in mice have also shown that Schizochytrium oil can improve markers of hepatic steatosis and inflammation.
However, the number of high-quality, large-scale human studies specifically using Schizochytrium oil for fatty liver disease remains limited. Most recommendations are extrapolated from the broader evidence base for omega-3 fatty acids in general. Thus, while there is scientific rationale and some direct evidence, the strength of evidence is moderate (3/5), and more research is needed to confirm its efficacy and optimal dosing.
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akkermansia muciniphilaalgal oil
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alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
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black garlic
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branched-chain amino acids
butyrate triglyceride
canola oil
catechins
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cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
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cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
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ashitaba
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Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
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Baicalein
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bile acid
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chlorogenic acid
Cynarin
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Chitin-Glucan Complex
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Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fucoidan
Fiber
Fucosterol
Fatty acids
Flavanones
Fucoxanthin
Flavonolignan
Glutathione
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walnut
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