Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rhaponticin is a stilbene compound found primarily in the roots of Rheum rhaponticum (rhapontic rhubarb). Recent preclinical studies have investigated its effects on fatty liver disease (hepatic steatosis), particularly in animal models. Evidence suggests that rhaponticin exhibits hepatoprotective properties, including the reduction of hepatic lipid accumulation and improvement of liver enzyme levels. Mechanistically, these effects have been attributed to its ability to modulate lipid metabolism, reduce oxidative stress, and suppress inflammatory pathways in the liver.

For example, a 2016 study in mice fed a high-fat diet demonstrated that rhaponticin supplementation reduced liver triglyceride content and improved histological markers of steatosis. The compound was also shown to regulate genes involved in lipid synthesis and breakdown, such as SREBP-1c and PPARα. Additionally, rhaponticin displayed antioxidant activity by increasing superoxide dismutase (SOD) levels and decreasing malondialdehyde (MDA), both markers associated with oxidative liver damage.

However, most of the available evidence comes from animal studies and in vitro experiments; there are currently no published clinical trials in humans directly evaluating rhaponticin for nonalcoholic fatty liver disease (NAFLD) or related conditions. Thus, while preliminary findings are promising, the scientific validation remains limited and further research, especially in humans, is required before definitive conclusions can be drawn regarding its efficacy and safety.

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Other ingredients used for Fatty Liver Disease

akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
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Baicalein
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Betanin
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bile acid
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Coriander
chlorogenic acid
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Caulerpa okamurae
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corosolic acid
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epicatechin
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Eucommia ulmoides
Fucoidan
Fiber
Fucosterol
Fatty acids
Flavanones
Fucoxanthin
Flavonolignan
Glutathione
Rhubarb
walnut
Zucchini

Other health conditions supported by Rhaponticin

Diabetes
Fatty Liver Disease
Inflammation
Menopause
Osteoporosis
Triglycerides (high)

Products containing Rhaponticin

We currently have no products on Caring Sunshine that contain this ingredient.