Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyphenols are a class of naturally occurring compounds found in plants, including fruits, vegetables, tea, coffee, and wine. Their use for fatty liver disease (specifically non-alcoholic fatty liver disease, NAFLD) is primarily supported by scientific research rather than traditional medicine. A growing body of preclinical and clinical studies suggests that polyphenols possess antioxidant, anti-inflammatory, and lipid-lowering properties that may be beneficial for liver health.

Animal studies have demonstrated that certain polyphenols, such as resveratrol (from grapes), epigallocatechin gallate (EGCG, from green tea), and curcumin (from turmeric), can reduce liver fat accumulation, improve insulin sensitivity, and decrease markers of liver inflammation.

In humans, small randomized controlled trials and meta-analyses have shown that supplementation with specific polyphenols (especially green tea extracts and resveratrol) can lead to modest improvements in liver enzyme levels and hepatic fat content in individuals with NAFLD. However, results are mixed and often limited by small sample sizes and short durations.

Overall, while there is promising evidence indicating a potential therapeutic role for polyphenols in managing fatty liver disease, the evidence is not yet strong enough to recommend their use as a stand-alone therapy. More large-scale, long-term human trials are needed to confirm their efficacy and safety. Nonetheless, increasing dietary intake of polyphenol-rich foods is considered beneficial for general health and may support liver function.

More about polyphenols
More about Fatty Liver Disease

Other ingredients used for Fatty Liver Disease

Other health conditions supported by polyphenols

Products containing polyphenols

Nature's Sunshine Grapine With Protectors (SynerPro)
Nature's Sunshine Super ORAC
Nature's Sunshine Super Trio