Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Centella triterpenes, the active compounds found in Centella asiatica (commonly known as gotu kola), are primarily used for fatigue based on traditional medicine practices rather than robust scientific validation. In Ayurveda and traditional Chinese medicine, gotu kola has been used as a "rejuvenating" herb, believed to support vitality, energy, and mental clarity. Historical texts describe its use for alleviating tiredness and improving cognitive function, particularly in contexts of general debility or convalescence.

Scientific evidence specifically linking Centella triterpenes to the treatment or support of fatigue is limited. A small number of animal studies suggest potential adaptogenic or neuroprotective effects, which might theoretically translate to anti-fatigue properties. However, human clinical trials directly evaluating Centella triterpenes for fatigue are scarce, and most available studies focus on other indications such as cognitive decline, wound healing, or anxiety.

In summary, the use of Centella triterpenes for fatigue is rooted in traditional herbal medicine practices, with limited scientific research to directly support its efficacy for this purpose. The current evidence base is insufficient to draw firm conclusions, and most claims rely on historical rather than modern clinical data.

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