Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ashwagandha (Withania somnifera), a prominent herb in Ayurvedic medicine, has a long tradition of use for enhancing vitality and reducing fatigue. Historically, it has been classified as a “rasayana,” or rejuvenating tonic, believed to support overall energy and resilience. In recent years, scientific interest has grown regarding its adaptogenic properties—its purported ability to help the body cope with stress and fatigue.

Multiple randomized, placebo-controlled trials have investigated ashwagandha’s effects on fatigue, particularly in the context of chronic stress and physical exertion. For example, studies in individuals with stress or anxiety have reported reductions in self-reported fatigue and improvements in energy levels with ashwagandha supplementation (typically 300-600 mg/day of root extract). Some research has also shown benefits in patients with chronic fatigue syndrome and in healthy adults exposed to strenuous physical activity, where ashwagandha improved measures of physical endurance and reduced perceived fatigue.

The proposed mechanisms include modulation of the hypothalamic-pituitary-adrenal (HPA) axis, reduction of cortisol levels, and enhancement of mitochondrial function. However, while data are promising, most studies are small and of short duration; larger, well-designed clinical trials are needed for definitive conclusions. Overall, both traditional use and emerging scientific evidence support ashwagandha’s potential to alleviate fatigue, but the evidence quality is moderate at present.

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