Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Potassium hydroxycitrate is a mineral salt form of hydroxycitric acid (HCA), a compound most commonly derived from the fruit Garcinia cambogia. The use of HCA-containing supplements for “fat metabolism” or weight management is primarily based on its purported ability to inhibit the enzyme ATP-citrate lyase, which is involved in the conversion of carbohydrates into fat in the body. Several preclinical studies and small human trials have examined HCA’s effects on body fat and weight loss, with mixed results.

Some randomized controlled trials have shown modest benefits in reducing fat accumulation or promoting weight loss, but meta-analyses and systematic reviews generally conclude that the effect size is small and not always clinically significant. For example, a 2011 meta-analysis (Onakpoya et al., J Obes. 2011) found that HCA supplementation led to a statistically significant, but clinically modest, greater weight loss compared to placebo. However, the studies reviewed were of variable quality and often short in duration. The specific potassium salt of hydroxycitrate may offer better bioavailability compared to other forms, but evidence for a significant improvement in fat metabolism remains limited.

Overall, the evidence supporting potassium hydroxycitrate for enhancing fat metabolism in humans is weak to moderate, with most authoritative sources suggesting that while there may be a small effect, it is not robust or consistent. Thus, the scientific justification exists, but the strength of evidence is low (rated 2 out of 5).

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